Surgical treatment of von Hippel-Lindau disease complicated by retinal detachment: a clinical case
https://doi.org/10.21516/2072-0076-2018-11-1-85-92
Abstract
A clinical case of surgical treatment of a patient with von Hippel-Lindau disease complicated by retinal detachment is presented. Intravitreal injection of ranibizumab was performed 7 days before vitrectomy. Laser photodestruction of retinal capillary hemangiomas was performed intraoperatively with an increased exposure and reduced inter-pulse interval. A 1 year follow-up showed a stable functional and anatomic result, and lack of relapse. Details of surgical treatment and advantages of the method proposed are discussed. For citation: Neroev V.V., Ilyukhin P.A., Ryabina M.V., Novikova A.Yu. Surgical treatment of von Hippel-Lindau disease complicated by retinal detachment: a clinical case. Russian ophthalmological journal. 2018; 11 (1):85-92. doi: 10.21516/2072-0076-2018-11-1-85-92 (In Russian).
About the Authors
V. V. Neroev
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
P. A. Ilyukhin
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
M. V. Ryabina
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
A. Yu. Novikova
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
References
1. Lonser R.R., Glenn G.M., Walther M., et al. von Hippel-Lindau disease. Lancet. 2003; 361 (9374): 2059-67.
2. Chew E.Y. Ocular manifestations of von Hippel-Lindau disease: clinical and genetic investigations. Trans. Am. Ophthalmol. Soc. 2005; 103: 495-511.
3. Neumann H.P., Wiestler O.D. Clustering of features of von Hippel-Lindau syndrome: evidence for a complex genetic locus. Lancet. 1991; 337: 1052 -54.
4. Webster A.R., Maher E.R., Moore A.T. Clinical characteristics of ocular angiomatosis in von Hippel-Lindau disease and correlation with germline mutation. Arch. Ophthalmol. 1999; 117(3): 371-8.
5. Chan C.C., Chew E.Y., Shen D., Hackett J., Zhuang Z. Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease. Mol. Vis. 2005; 11: 697-704.
6. Nicholson D.H., Green W.R., Kenyon K.R. Light and electron microscopic study of early lesions in angiomatosis retinae. Am. J. Ophthalmol. 1976; 82(2): 193-204.
7. von Hippel E. Uber eine sehr seltene Erkrankung der Netzhaut. Graefes Arch Ophthalmol. 1904; 59: 83-106.
8. Lindau A. Studien ber Kleinbirncysten Bau. Pathogenese und Beziehungen zur Angiomatosis Retinae. Acta Pathol Microbiol Scand. 1926; 3(1): 1-28.
9. Latif F., Tory K., Gnarra J., et al. Identification of the von Hippel-Lindau disease tumour suppressor gene. Science. 1993; 260:1317-20.
10. Kaelin W.G. Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer. 2002; 2: 673-82.
11. Hewitson K.S., McNeill L.A., Schofield C.J. Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer. Curr Pharm Des. 2004; 10(8): 821-33.
12. Kim H., Yi J.H., Kwon H.J., Lee C.S., Lee S.C. Therapeutic outcomes of retinal hemangioblastomas. Retina. 2014; 34(12): 2479-86. doi: 10.1097/IAE.0000000000000254.
13. Suh C.S., Jin S.Y., Bae S.H., Kim C.G., Kim J.W. Retinal capillary hemangioma treated with verteporfin photodynamic therapy and intravitreal triamcinolone acetonide. Korean J Ophthalmol. 2007; 21(3): 178-184. doi:10.3341/kjo.2007.21.3.178.
14. Gass J.D.M. Stereoscopic atlas of macular diseases. St. Louis etc.: CV Mosby Co.; 1977
15. Singh A.D., Shields C.L., Shields J.A. von Hippel-Lindau disease. Surv. Ophthalmol. 2001; 46: 117-142.
16. Russo V., Stella A., Barone A., Scott I.U., Noci N.D. Ruthenium-106 brachytherapy and intravitreal bevacizumab for retinal capillary hemangioma. Int. Ophthalmol. 2012; 32: 71-5.
17. Papastefanou V.P., Pilli S., Stinghe A., Lotery A.J., Cohen V.M.L. Photodynamic therapy for retinal capillary hemangioma. Eye. 2013; 27: 438-442. doi:10.1038/eye.2012.259
18. Mochizuki Y., Noda Y., Enaida H., et al. Retinal capillary hemangioma managed by transpupillary thermotherapy. Retina. 2004; 24(6): 981-4.
19. Сидорова Ю.А., Белый Ю.А., Терещенко А.В. Интраокулярная фотодинамическая терапия в лечении ангиоматоза сетчатки при проведении витреоретинальных вмешательств (клинический случай). Современные технологии в офтальмологии. 2014; 1: 95-6.
20. Krzystolik K., Stopa M., Kuprjanowicz L., et al. Pars plana vitrectomy in advanced cases of Von Hippel-Lindau eye disease. Retina 2016; 36(2): 325 - 334. doi:10.1097/IAE.0000000000000707.
21. Gaudric A., Krivosic V., Duquid G., et al. Vitreoretinal surgery for severe retinal capillary hemangiomas in Von Hippel-Lindau Disease. Ophthalmology. 2011; 118(1):142-9. doi: 10.1016/j.ophtha.2010.04.031.
Review
For citations:
Neroev V.V., Ilyukhin P.A., Ryabina M.V., Novikova A.Yu. Surgical treatment of von Hippel-Lindau disease complicated by retinal detachment: a clinical case. Russian Ophthalmological Journal. 2018;11(1):85-92. (In Russ.) https://doi.org/10.21516/2072-0076-2018-11-1-85-92
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