The impact of phacoemulsification on corneal endothelial cells in patients with pseudoexfoliation syndrome
https://doi.org/10.21516/2072-0076-2019-12-1-50-55
Abstract
The effect of pseudoexfoliation syndrome (PEХ) on endothelial cells has been studied long enough. Yet the effect of phacoemulsification (PHACO) on endothelium in patients with PEХ is less explored. Purpose. To assess the impact of PHACO on corneal endothelial cell density (ECD) and on the coefficient of variation (CV) in patients with PEX. Material and methods. 30 patients (30 eyes) with PEX syndrome and 34 patients (34 eyes) with no such syndrome were examined before and after phacoemulsification. Results. In patients with PEX, the ECD after PHACO was significantly lower and CV was significantly higher (р < 0.05). Conclusion. PEX has a negative impact on endothelial cells, which leads to a pronounced cells loss after PHACO.
About the Authors
V. V. Potemkin
St. Petersburg Pavlov State Medical University
City Ophthalmologic Center of City hospital No. 2
Russian Federation
Russian Federation
Cand. Med. Sci., ophthalmologist, assistant professor, chair of ophthalmology
6–8, Bldg 16, Lev Tolstoy St., St. Petersburg, 197089, Russia
5, Uchebny pereulok, St. Petersburg, 194354, Russia
T. S. Varganova
City Ophthalmologic Center of City hospital No. 2
Russian Federation
Russian Federation
Cand. Med. Sci., ophthalmologist
5, Uchebny pereulok, St. Petersburg, 194354, Russia
E. V. Ageeva
City Ophthalmologic Center of City hospital No. 2
Russian Federation
Russian Federation
ophthalmologist
5, Uchebny pereulok, St. Petersburg, 194354, Russia
References
1. Ritch R., Schl tzer-Schrehardt U., Konstas A.G.P. Why is glaucoma associated with exfoliation syndrome? Prog Retin Eye Res. 2003; 22 (3): 253–75. doi.org/10.1016/S1350-9462(02)00014-9
2. Martone G., Casprini F., Traversi C., et al. Pseudoexfoliation syndrome: in vivo confocal microscopy analysis. Clinical and Experimental Ophthalmology. 2007; 35 (6): 582–585. doi.org/10.1111/j.1442-9071.2007.01535.x
3. Ritch R., Schlötzer-Schrehardt U. Exfoliation syndrome. Survey of Ophthalmology. 2001; 45 (4): 265–315. doi.org/10.1016/S0039-6257(00)00196-X
4. Schlötzer-Schrehardt U., Naumann G.O. Ocular and systemic pseudoexfoliation syndrome. American Journal of Ophthalmology. 2006; 141(5): 921–33.
5. Schumacher S., Schlötzer-Schrehardt U., Martus P., Lang W., Naumann G.O. Pseudoexfoliation syndrome and aneurysms of the abdominal aorta. The Lancet. 2001; 357 (9253): 359–60. doi.org/10.1016/S0140-6736(00)03645-X
6. Naumann G. O. H., Schlötzer-Schrehardt U. Keratopathy in pseudoexfoliation syndrome as a cause of corneal endothelial decompensation. Ophthalmology. 2000; 107 (6): 1111–24. doi.org/10.1016/S0161-6420(00)00087-7
7. Kohnen T. Corneal endothelium: an important structure for cataract and refractive procedures. J. Cataract. Refract. Surg. 1997; 23: 967–8. doi.org/10.1016/S0886-3350(97)80055-7
8. Rao S.K., Ranjan Sen P., Fogla R., et al. Corneal endothelial cell density and morphology in normal Indian eyes. Cornea. 2000; 19: 820–3. doi.org/10.1097/00003226-200011000-00012
9. Miyake K., Matsuda M., Inaba M. Corneal endothelial changes in pseudoexfoliation syndrome. Am. J. Ophthalmol. 1989; 108: 49–52. doi.org/10.1016/S0002-9394(14)73259-3
10. Hattori Y. Corneal endothelial examination of pseudoexfoliation syndrome. Nippon Ganka Gakkai Zasshi (Acta Soc Ophthalmol Jpn) 1990; 94: 957–63.
11. Wang L., Yamashita R., Hommura S. Corneal endothelial changes and aqueous flare intensity in pseudoexfoliation syndrome. Ophthalmologica. 1999; 213: 387–91. doi.org/10.1159/000027460
12. Seitz B., Müller E.E., Langenbucher A., Kus M.M., Naumann G.O. Endothelial keratopathy in pseudoexfoliation syndrome: quantitative and qualitative morphometry using automated video image analysis. Klin. Monatsbl. Augenheilkd. 1995; 207: 167–75. doi.org/10.1055/s-2008-1035363
13. Knorr H.L., Jünemann A., H ndel A, Naumann G.O.H. Morphometric and qualitative changes in corneal endothelium in pseudoexfoliation syndrome. Fortschr. Ophthalmol. 1991; 88: 786–9.
14. Wirbelauer C., Anders N., Pham D.T., Wollensak J. Corneal endothelial сell changes in pseudoexfoliation syndrome after cataract surgery. Arch Ophthalmol. 1998; 116: 145–9. doi.org/10.1001/archopht.116.2.145
15. Wirbelauer C., Anders N., Pham D.T., Holschbach A., Wollensak J. Early postoperative endothelial cell loss after corneoscleral tunnel incision and phacoemulsification in pseudoexfoliation syndrome. Der Ophthalmologe. 1997; 94: 332–6, doi.org/10.1007/s003470050124
16. Chylack L.T.Jr., Wolfe J.K., Singer D.M., et al. The Lens Opacities Classification System III. Arch. Ophthalmol. 1993; 111 (6): 831–6. doi:10.1001/archopht.1993.01090060119035
17. Schlötzer-Schrehardt U., Naumann G.O. A histopathologic study of zonular instability in pseudoexfoliation syndrome. Am. J. Ophthalmol. 1994; 118: 730–43. doi.org/10.1016/S0002-9394(14)72552-8
18. Shingleton B.J., Crandall A.S., Ahmed II. Pseudoexfoliation and the cataract surgeon: preoperative, intraoperative, and postoperative issues related to intraocular pressure, cataract, and intraocular lenses. J Cataract Refract Surg. 2009; 35:1101–20. doi.org/10.1016/j.jcrs.2009.03.011
19. Vazquez-Ferreiro P., Carrera-Hueso F.J., Poquet Jornet J.E., et al. Intraoperative complications of phacoemulsification in pseudoexfoliation: meta-analysis. J. Cataract. Refract. Surg. 2016; 42 (11): 1666–75. doi.org/10.1016/j.jcrs.2016.09.010
20. Zheng Х., Shiraishi A., Okuma Sh., et al. In vivo confocal microscopic evidence of keratopathy in patients with pseudoexfoliation syndrome. Invest. Ophthal. Vis. Sci. 2011 March; 52: 1755–61.
21. McCarey B.E., Edelhauser H.F., Lynn M.J. Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions. Cornea. 2008 Jan; 27 (1): 1–16. doi.org/10.1097/ICO.0b013e31815892da
22. Bourne R.R., Minassian D.C., Dart J.K., et al. Effect of cataract surgery on the corneal endothelium: modern phacoemulsification compared with extracapsular cataract surgery. Ophthalmology. 2004; 111: 679–85. doi.org/10.1016/j.ophtha.2003.07.015
23. Cheng H., Jacobs P.M., McPherson K., Noble M.J. Precision of cell density estimates endothelial cell loss with age. Arch. Ophthalmol. 1985; 103: 1478–81. doi.org/10.1001/archopht.1985.01050100054017
24. Abib F.C. Microscopia Especular de Córnea. Manual e Atlas. Rio de Janeiro: Revinter, 2000.
25. Schlötzer-Schrehardt U.M., Dörfler S., Naumann G.O. Corneal endothelial involvement in pseudoexfoliation syndrome. Arch. Ophthalmol. 1993 May; 111 (5): 666–74.
26. Naumann G.O., Schlötzer-Schrehardt U. Keratopathy in pseudoexfoliation syndrome as a cause of corneal endothelial decompensation: A clinicopathologic study. Ophthalmology. 2000; 107 (6): 1111–24. doi.org/10.1016/S0161-6420(00)00087-7
27. Demirdögen B.C., Ceylan O.M., Işikoğlu S., Mumcuoğlu T., Erel O. Evaluation of oxidative stress and paraoxonase phenotypes in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Clin Lab 2014; 60 (1): 79–86. doi.org/10.7754/Clin.Lab.2013.121229
28. Patel S., McLaren J., Hodge D., Bourne W. Normal human keratocyte density and corneal thickness measurement by using confocal microscopy in vivo. Invest. Ophthalmol. Vis. Sci. 2001; 42 (2): 333–9.
29. Schlötzer-Schrehardt U., Naumann G.O.H. Ocular and systemic pseudoexfoliation syndrome. Am. J. Ophthalmol. 2006; 141 (5): 921–37. doi.org/10.1016/j.ajo.2006.01.047
30. Sein J., Galor A., Sheth A., et al. Exfoliation syndrome: New genetic and pathophysiologic insights. Curr. Opin. Ophthalmol. 2013; 24 (2): 167–74. doi.org/10.1097/ICU.0b013e32835d5d11
31. Sbeity Z., Palmiero P.-M., Tello C., Liebmann J.M., Ritch R. Noncontact in vivo confocal scanning laser microscopy in exfoliation syndrome, exfoliation syndrome suspect and normal eyes. Acta Ophthalmol. 2011; 89 (3): 241–7. doi.org/10.1111/j.1755-3768.2009.01678.x
32. Ritch R. Exfoliation syndrome. Curr. Opin. Ophthalmol. 2001; 12 (2): 124–30. doi.org/10.1097/00055735-200104000-00008
33. Küchle M., Vinores S.A., Mahlow J., Green W.R. Blood-aqueous barrier in pseudoexfoliation syndrome: Evaluation by immunohistochemical staining of endogenous albumin. Graefes Arch. Clin. Exp. Ophthalmol. 1996; 234 (1): 12–8. doi.org/10.1007/BF00186513
34. Miyake K., Matsuda M., Inaba M. Corneal endothelial changes in pseudoexfoliation syndrome Am. J. Ophthalmol. 1989; 108: 49–52. doi.org/10.1016/S0002-9394(14)73259-3
35. Knorr H.L., Junemann A., Handel A., Naumann G.O. Morphometric and qualitative changes in corneal endothelium in pseudoexfoliation syndrome. Fortschr Ophthalmol. 1991; 88: 786–9.
36. Quiroga L., Lansingh V.C., Samudio M., Peña F.Y., Carter M.J. Characteristics of the corneal endothelium and pseudoexfoliation syndrome in patients with senile cataract. Clin. Exp. Ophthalmol. 2010 Jul; 38 (5): 449–55.
37. Inoue K., Okugawa K., Oshika T., Amano S. Morphological study of corneal endothelium and corneal thickness in pseudoexfoliation syndrome. Jpn J Ophthalmol. 2003; 47: 235–9. doi.org/10.1016/S0021-5155(03)00022-4
38. Ostern A.E., Drolsum L. Corneal endothelial cells 6–7 years following cataract surgery in patients with pseudoexfoliation syndrome. Acta Ophthalmol. 2012; 90: 408–11. doi.org/10.1111/j.1755-3768.2010.02012.x
39. Palko J.R., Qi O., Sheybani A. Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: a literature review. J. Ophthalmic Vis. Res. 2017 Jul-Sep; 12 (3): 312–24. doi:10.4103/jovr.jovr_28_17
Review
For citations:
Potemkin V.V., Varganova T.S., Ageeva E.V. The impact of phacoemulsification on corneal endothelial cells in patients with pseudoexfoliation syndrome. Russian Ophthalmological Journal. 2019;12(1):50-55. (In Russ.) https://doi.org/10.21516/2072-0076-2019-12-1-50-55
Views:
918
Email this article 