A comparative evaluation of efficiency of fixed combination hypotensives for the treatment of primary open-angle glaucoma
https://doi.org/10.21516/2072-0076-2016-9-4-5-10
Abstract
Purpose. To compare hypotensive efficiency and safety of fixed combinations of drugs treating primary open-angle glaucoma (POAG). Material and methods. We conducted a randomized prospective clinical trial which involved 80 patients (158 eyes) divided into 4 groups) and lasted six months. The patients received timolol 0.5 % + travoprost 0.004 % (group1), timolol 0.5 % + brimonidine 0.2 % (group 2), timolol 0.5 %+brinzolamide 1 % (group 3) and timolol 0.5 % + pilocarpin 2 % (group 4). Results. All fixed drug combinations compared were found to produce a hypotensive effect in the treatment of POAG patients. Over 6 months, IOP dropped by 20.6 % to 33.1 % against the initial level. The best and the longest-lasting effect was achieved when the first combination, timolol+travoprost (jointly called duotrav), was used. Conclusion. The Duotrav combination should be prescribed for long-term treatment of POAG and ocular hypertension. Timolol + brimonidine and timolol + brinzolamide are the most effective in short-term therapy of POAG and ocular hypertension, as well as in the pre-operative period prior to surgeries of glaucoma with high IOP. After normal IOP values have been obtained, the patient should be prescribed Duotrav, which is a more stable combination. Travoprost 0.004 %/timolol with 0.5 % is more effective, stabile and safe combination and recommend for long-term therapy of. Even though the combination of timolol and pilocarpin is not generally recommended for POAG therapy, it can be used for short-term inexpensive POAG and ocular hypertension treatment // Russian Ophthalmological Journal, 2016; 4: 5-10. doi: 10.21516/2072-0076-2016-9-4-5-10.
About the Authors
F. A. Bakhritdinova
Tashkent Medical Academy, Ministry of Health, Uzbekistan
Russian Federation
Russian Federation
S. Sh. Mirrakhimova
Tashkent Medical Academy, Ministry of Health, Uzbekistan
Russian Federation
Russian Federation
U. R. Karimov
Syrdarya Regional Ophthalmological Hospital, Gulistan, Uzbekistan
Russian Federation
Russian Federation
A. . Khera
Vedania Medical Clinic, Tashkent, Uzbekistan
Russian Federation
Russian Federation
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Review
For citations:
Bakhritdinova F.A., Mirrakhimova S.Sh., Karimov U.R., Khera A. A comparative evaluation of efficiency of fixed combination hypotensives for the treatment of primary open-angle glaucoma. Russian Ophthalmological Journal. 2016;9(4):5-10. (In Russ.) https://doi.org/10.21516/2072-0076-2016-9-4-5-10
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